https://rheumatologydigest.org/tags/pathophysiology/Recent content in Pathophysiology on Rheumatology DigestHugoen-usThu, 21 May 2026 07:11:06 +0530https://rheumatologydigest.org/posts/gc-ef-b-cell-pathways-sle/Thu, 21 May 2026 07:11:06 +0530https://rheumatologydigest.org/posts/gc-ef-b-cell-pathways-sle/This 2026 Nature Reviews Rheumatology paper reframes SLE autoantibody production by contrasting the germinal-centre and extrafollicular B cell pathways — their distinct kinetics, affinity profiles, T cell dependence, and therapeutic vulnerabilities — showing that the inflammatory niche, not intrinsic autoreactivity, determines pathogenic B cell fate.