Early Methylprednisolone Pulses and Long-Term Damage in Active SLE

A propensity-score analysis of the Lupus–Cruces–Bordeaux inception cohort: early (first-year) methylprednisolone pulses were associated with a ~40% reduction in long-term irreversible damage or death in active SLE, with benefit concentrated in moderate–severe disease — likely reflecting an MP-anchored low-steroid strategy rather than the molecule alone.

June 28, 2026 · 7 min

Screening, Monitoring and Treatment of ILD in Systemic Sclerosis

A 2026 practical distillation of the 2023 ACR/CHEST guidelines on SSc-ILD — the single leading cause of death in systemic sclerosis. Covers proper screening (full PFTs + non-contrast HRCT), monitoring schedules, the first-line drug evidence (mycophenolate, tocilizumab, rituximab, nintedanib), and the strong recommendation against glucocorticoids.

June 26, 2026 · 7 min

Fertility, Pregnancy and Lactation in Women with SLE

A 2026 narrative review of fertility, pregnancy and lactation in SLE — the bidirectional disease–pregnancy relationship, the immunobiology of placental injury, and contemporary peri-conception, pregnancy and lactation care anchored to BSR, EULAR and ACR guidance, including a drug-by-drug safety framework.

June 14, 2026 · 8 min

EULAR 2025 Recommendations for the Management of Rheumatoid Arthritis

The 2025 EULAR update streamlines RA management to 5 overarching principles and 9 recommendations, abandons post-methotrexate prognostic risk stratification, and keeps JAK inhibitors co-equal with biologics after individual risk assessment.

June 5, 2026 · 8 min

Recombinant Zoster Vaccine in Inflammatory Rheumatic Disease — Efficacy, Long-Term Protection and Safety Under Immunosuppression

A 2026 RMD Open narrative review of recombinant zoster vaccine (RZV) in inflammatory rheumatic disease — robust efficacy across IRD cohorts (~95% reduction in HZ recurrence; 54–70% effectiveness in SLE), no meaningful short-term flare signal in RCT data, and a practical drug-by-drug timing framework spanning csDMARDs, biologics, JAK inhibitors and B-cell depletion.

May 25, 2026 · 11 min

A Phase 3 Trial of Brepocitinib in Dermatomyositis (VALOR Trial)

The VALOR phase 3 trial shows that brepocitinib 30 mg daily — a selective TYK2–JAK1 inhibitor — significantly improves composite disease activity, skin involvement, and muscle strength while enabling steroid discontinuation in adults with treatment-refractory dermatomyositis, marking the first successful phase 3 RCT of an oral targeted agent in this disease.

May 20, 2026 · 8 min